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. 2022 May 13;145(10):3472–3487. doi: 10.1093/brain/awac176

Figure 4.

Figure 4

Serum lipid profiles discriminate LRRK2 G2019S carriers from non-LRRK2 G2019S carriers in the LRRK2 Ashkenazi Jewish Cohort. Multivariate ANOVA covarying for age and sex identified four principal components, (A) PC41, (B) PC57, (C) PC63 and (D) PC73, that were significantly different between the LRRK2 mutation and non-mutation groups. (E–H) The top 20 lipid species that contributed to the top four components which significantly distinguished between LRRK2 mutation and non-mutation groups. The dashed red line represents the expected value if the contribution of lipids were uniform. n = 315. WT = wild-type.