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. 2022 May 13;145(10):3472–3487. doi: 10.1093/brain/awac176

Figure 5.

Figure 5

Sphingolipids and glycerolipids and altered in multi-ethnic LRRK2 cohort CSF. Two-factor multivariate analysis covarying for age and sex revealed a significant effect of both Parkinson’s disease and LRRK2 G2019S mutation (both P < 0.05) on CSF lipid profiles. (A–G) Post hoc analysis identified sphingolipids and glycerolipids were different between Parkinson’s disease patient and control CSF samples. (H–J) Glycerolipid and sphingolipid species were significantly different between LRRK2 G2019S mutation carriers and non-carriers. n = 88. WT = wild-type.