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. 2022 May 13;145(10):3472–3487. doi: 10.1093/brain/awac176

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Implicated lipids are metabolically linked in Parkinson’s disease risk gene pathways. Pathway analysis was performed to generate a metabolic map of the main lipid classes implicated in the discrimination of Parkinson’s disease patients and LRRK2 carriers from controls. The resulting map indicated that most implicated lipids were highly integrated and were in metabolic pathways that included enzymes encoded by Parkinson’s disease risk genes (GBA1, GALC, SMPD1, PLA2G6 and DGKQ). GCase = glucocerebrosidase; GALCase = galactoceramidase; SMase = sphingomyelinase; CaI-PLA2 = 85/88 kDa calcium-independent phospholipase A2; PA = phosphatidic acid; PI(4)P = phosphatidylinositol-4-phosphate. #PG is formed from PA in a three-step reaction pathway.