Table 1. General patient information, clinical data, and classification of alterations according to American College of Medical Genetics and Genomics criteria.

ID	Sex/Age	TS (%) / and SF (μg/L) 2016	TS (%) / and SF (μg/L) 2020	Liver iron concentration (mg/g) 2020	FTL variants	ACMG criteria	ACMG
#01	Female/41	28/1,487	33/1,434	1.0	c-164 C>A	PS, PM, PP	Pathogenic
#02	Female/67	46/1,703	34/2,145	1.3	c-164 C>A	PS, PM, PP	Pathogenic
#03	Male/11	28/1,260	46/1,308	0.8	c-164 C>A	PS, PM, PP	Pathogenic

ID: identification; TS: transferrin saturation; SF: serum ferritin; PS: pathogenic strong; PM: pathogenicity moderate; PP: pathogenicity supplementary; FTL: ferritin light chain; ACMG: American College of Medical Genetics and Genomics.