Figure 5.

Ogfod1 ablation leads to protection against damage resulting from in vivo LAD artery ligation. (A) In vivo ischaemia reperfusion injury was induced by left anterior descending (LAD) coronary artery ligation in WT and KO mice as shown in the schematic. (B) Area at risk (AAR) for WT and KO hearts subjected to LAD artery ligation. (C) Infarct size shown as a percentage of the heart. Data shown as mean ± standard error. n = 8 biological replicates per group. Student’s t-test with Welch’s correction was used to determine significance between groups. A P-value of <0.05 was considered significant.