Figure 7.

Carnosine treatment protects WT, but not KO hearts from ischaemia–reperfusion injury. (A) Schematic showing the ischaemia–reperfusion protocol as well as the carnosine and vehicle treatments. (B) Infarct size measured at the end of the ischaemia–reperfusion period. (C) Rate pressure product (RPP) recovery following ischaemia and reperfusion. Data shown as mean ± standard error. n = 7–9 biological replicates per group. Brown–Forsythe and Dunnett’s T3 multiple comparisons tests were used to compare more than two groups. A P-value of <0.05 was considered significant. LVDP, left ventricular developed pressure; TTC, 2,3,5-triphenyltetrazolium chloride.