Table 3.

Significant DMR associated with top tertile liver fat content (by MRI-PDFF).

Gene	# of CpG	Chr.	max. β	Area	FDR P-value	Gene Ontology/Annotation
MROH6	13	Chr 8	−0.007	PROMOTER	3.3 x 10−[8]	IL18, body fat percentage/Variant may regulate inflammasome
CDH24	4	Chr 14	−0.0031	PROMOTER	1.2 x 10−[7]	Cell morphogenesis, cell-cell junction assembly/Binds catenins, alterations implicated in several cancers
WFIKKN2	20	Chr 17	0.005	PROMOTER	1.4 x 10−[7]	Skeletal system development, TGFβ-R signalling pathway/Loss of function variant associated with glucose, haemoglobin A1c and HOMA-IR in humans
FGFBP1	9	Chr 4	−0.0067	GENE_BODY	2.4 x 10−[7]	Signal transduction, cell-cell signalling/Increased gene expression associated with familial hypertension
TMEM232	14	Chr 5	−0.013	PROMOTER	8.9 x 10−[6]	Membrane component/Variant associated with atopic dermatitis
KCNG2	6	Chr 18	0.008	GENE_BODY	1.1 x 10−[5]	Ion transport, regulation of insulin secretion/Regulation of neurotransmitters, heart rate, transport
AKAP8L	6	Chr 19	−0.007	PROMOTER	1.1 x 10−[5]	mRNA processing, mitotic chromosome condensation/Regulation of H3K4 histone methyltransferase complexes, apoptosis, DNA replication
WIZ	6	Chr 19	−0.007	DOWNSTREAM	1.1 x 10−[5]	Regulation of transcription, cell cycle/Aberrant methylation associated with atherosclerosis risk subtype
SLC6A20	4	Chr 3	−0.005	INTRON	4.3 x 10−[5]	Amino acid transport, glycine transport/Variants associated with increased risk for diabetes, kidney transporters
SCO2	6	Chr22	−0.005	PROMOTER	4.7 x 10−[5]	In utero embryonic development, copper transport/Cytochrome c oxidase assembly, mitochondrial copper delivery pathways

Analysis adjusted for mother’s pre-pregnancy body mass index, mother’s age at delivery, child sex, maternal smoking and cell proportions. DMR, differentially methylation region; Chr, chromosome; FDR, false discovery rate; TSS, transcription start site.