Table 1.
Description of the cohort.
| Group | Cases (MS) | Controls (NNC) |
|---|---|---|
| N individuals | 8 | 14 |
| Sex ratio (F/M) | 8:0# | 4:10 |
| Age (mean ± SD) | 63.1 ± 12.6* | 76.4 ± 13.4 |
| PMI (mean ± SD)a | 15.6 ± 8.6 | 21.8 ± 7.7 |
| N brain samples Type lesion (N) |
15 NAWM (15) |
23 - |
| Fraction 1 (% ± SD) Fraction 2 (% ± SD) Fraction 3 (% ± SD) |
36.6 ± 28.2* 39.2 ± 28.5* 23.8 ± 23.8 |
61.1 ± 24.3 11.0 ± 10.8 27.3 ± 23.6 |
MS, Multiple Sclerosis, NNC, non-neurological disease controls, N, number, F/M, female/male, PMI, post-mortem interval, NAWM, normal-appearing white matter, aPMI not available for 4 control individuals. Cell fractions were determined by RefFreeEwas cell type deconvolution. # P-value < 0.05 between cases and controls by chi-square (Χ2) test, * P-value < 0.05 between cases and controls generated by two-tailed independent samples T test.