Table 3.
Linear regression models linking female epigenetic clocks at 20–22 years of age to birth weight (adjusted for gestational age) and their mother’s arm fat area (MAFA) during pregnancya.
| Model 1 | Model 2 | Full model | |||
|---|---|---|---|---|---|
| Horvath | |||||
| Birth weight | 0.183 (0.350) | 0.230 (0.357) | |||
| MAFA | −0.015 (0.026) | −0.019 (0.027) | |||
| Model adj. R2 | 0.000 | 0.000 | 0.000 | ||
| Hannum | |||||
| Birth weight | −0.043 (0.297) | 0.24 (0.303) | |||
| MAFA | −0.026 (0.022) | −0.026 (0.023) | |||
| Model adj. R2 | 0.038 | 0.039 | 0.038 | ||
| DNAmTL | |||||
| Birth weight | 0.002 (0.012) | 0.002 (0.012) | |||
| MAFA | −0.0002 (0.0009) | −0.0002 (0.0009) | |||
| Model adj. R2 | 0.060 | 0.060 | 0.059 | ||
| DNAmPhenoAge | |||||
| Birth weight | 0.265 (0.376) | 0.368 (0.374) | |||
| MAFA | −0.036 (0.028) | −0.041 (0.028) | |||
| Model adj. R2 | 0.092 | 0.093 | 0.093 | ||
| DNAmGrimAge | |||||
| Birth weight | −0.283 (0.193) | −0.233 (0.196) | |||
| MAFA | −0.023 (0.015) | −0.020 (0.015) | |||
| Model adj. R2 | 0.154 | 0.155 | 0.155 | ||
| DunedinPACE | |||||
| Birth weight | −0.012 (0.01) | −0.012 (0.01) | |||
| MAFA | 0.0002 (0.0007) | 0.0003 (0.0007) | |||
| Model adj. R2 | 0.194 | 0.192 | 0.193 | ||
aregression coefficients (SE). All models adjust for adult BMI, highest grade completed, household income, current pregnancy status, and daily smoking (see Supplemental Tables 2–9 for full models).