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Mechanism underlying the effects of AS-IV after MI. MI induced mitochondria ROS production, activated the ROS/NLRP3/GSDMD pathway, AS-IV intervention inhibiting the production of ROS and the expression of NLRP3, cleaved cas-1, cleaved IL-1β, cleaved IL-18 and GSDMD-N, thus ameliorating myocardial fibrosis and cardiac remodeling.
