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Doxorubicin-induced myocardial mitochondrial substrate metabolism disorder. Abbreviations. AKT: serine/threonine kinase; GLUT1: glucose transporter 1, IFNγ: interferon gamma; IFNγR: interferon gamma receptor; AMPK: adenosine 5′-monophosphate (AMP)-activated protein kinase; ACC: acetyl-CoA carboxylase; ERK: extracellular regulated protein kinases; FAO: fatty acid oxidation; CPT1: carnitine palmitoyltransferase 1; PFK phosphofructokinase; CS citrate synthase.
