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. 2022 Oct 17;3(10):1181–1191. doi: 10.1038/s43018-022-00439-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — Cohort B enrolled patients with advanced HER2-negative breast cancer or other solid tumors lacking a germline BRCA1 or BRCA2 mutation with either a germline or somatic mutation in a gene associated with HR-deficiency. Patients were treated with single-agent talazoparib in an initial cohort of 10 patients. On the basis of observed responses in the first 10 patients, an additional 10 patients were enrolled and treated.