Table 1.
. A summary of the data available for homologs of the EMC components in two model apicomplexans, Toxoplasma gondii, and Plasmodium falciparum. Fitness scores for Toxoplasma are from the study by Sidik et al. [40], and for Plasmodium falciparum are from a PiggyBac screen [41]. In both, lower score reflects higher contribution to fitness. Localisation prediction is based on localisation of organelle proteins by isotope tagging in Toxoplasma [42]. Presence in a complexome analysis provides evidence for belonging to the same complex [17].
Toxoplasma gondii |
Plasmodium falciparum |
|||||
---|---|---|---|---|---|---|
Gene ID | Fitness-conferring score | Localisation prediction | Gene ID | Present in complexome analysis | Fitness-conferring score | |
EMC1 | TGME49_205740 | −5.03 | ER | PF3D7_0811200 | Yes | −3.23 |
EMC2 | TGME49_267840 | −4.08 | ER | PF3D7_1410000 | Yes | −3.42 |
EMC3 | TGME49_230100 | −3.02 | ER | PF3D7_1360200 | Yes | −2.81 |
EMC4 | TGME49_259000 | −4.77 | ER | PF3D7_1435400 | Yes | −3.3 |
EMC5 | TGME49_293200 | −2.68 | ER | PF3D7_0306700 | Yes | −3.39 |
EMC6 | TGME49_239690 | −3.57 | No data | PF3D7_1214400 | No | −2.76 |
EMC7 | TGME49_243390 | −1.71 | ER | PF3D7_1310500 | Yes | −3.08 |
EMC8 | TGME49_249310 | −4.1 | ER | PF3D7_1139900 | Yes | −2.84 |