Table 2.

Pattern of susceptibility to live attenuated vaccines according to IUIS category and subcategory of IEI

IUIS disease category	Inborn error of immunity	Live viral vaccine							References
		Measles	Mumps	Rubella	Varicella	Rotavirus	Yellow fever	Poliovirus
1. Immunodeficiencies affecting cellular and humoral immunity	T-B+ SCID			x	x	x			[5−9,46]
	T-B- SCID		x	x	x	x		x	[5,9,41,50,51,56,62,85]
	CID			x				x	49, 50, 51,84]
2. Combined immunodeficiencies with associated or syndromic features	DNA repair defects			x					[48, 49, 50, 51,52•]
	DiGeorge syndrome			x					[52•]
	Cartilage hair hypoplasia			x					[49,51]
3. Predominantly antibody deficiencies	Agammaglobulinemia							x	[76,86, 87, 88]
	APDSa			x	x				[48,50,58,59]
6. Defects in intrinsic and innate immunity	WHIM			x					[51]
	Predisposition to severe viral infection	x	x	x	x		x		[26,27••,29,39,40,67,72•]

^aArguably, APDS is more correctly classified as a combined immunodeficiency with syndromic features.