Effect of reducing MC activity on whisker-evoked wS1 spiking activity in response to varying whisker deflection amplitude or velocity. (A-B) Average number of evoked spikes (over a 30 ms response window) across the different whisker deflection paradigms with varying deflection amplitudes (A) or velocities (B). Data from MCTeNT mice are displayed in blue. (*) Indicates that spiking activity in controls significantly decreases when deflection amplitude or velocity is varied (Friedman test). Dashed lines link medians. (C-D) Population PSTHs (average response over 60 sweeps, bin width 10 ms) for each deflection paradigm with varying amplitude (C) or velocity (D). (A-D) Varying amplitude: CON, n = 9; MCTeNT, n = 10 - Varying velocity: CON, n = 8; MCTeNT, n = 7.