TABLE 3.
Results From Multivariable Logistic Regression Analyses, With Separate Models for Each Biomarker Variable
| Biomarker Variables | Adjusted OR for Acute Respiratory Distress Syndrome Developmenta | 95% CI | p |
|---|---|---|---|
| log (sRAGE level), day 1 | 1.55 | 0.81–2.94 | 0.18 |
| Δ sRAGE, day 1 to 2 | 0.73 | 0.36–1.45 | 0.36 |
| Δ sRAGE, day 1 to 3 | 0.80 | 0.46–1.40 | 0.43 |
| log (Ang-2 level), day 1 | 1.21 | 0.53–2.74 | 0.65 |
| Δ Ang-2, day 1 to 2 | 1.04 | 0.92–1.17 | 0.57 |
| Δ Ang-2, day 1 to 3 | 0.99 | 0.88–1.11 | 0.82 |
| log (SP-D level), day 1 | 1.53 | 0.97–2.42 | 0.07 |
| Δ SP-D, day 1 to 2 | 1.04 | 0.97–1.11 | 0.32 |
| Δ SP-D, day 1 to 3 | 1.01 | 0.96–1.07 | 0.72 |
| Biomarker Variables | Adjusted OR for Mortalityb | 95% CI | p |
| log (sRAGE level), day 1 | 1.57 | 0.99–2.48 | 0.06 |
| Δ sRAGE, day 1 to 2 | 1.04 | 0.58–1.88 | 0.90 |
| Δ sRAGE, day 1 to 3 | 0.94 | 0.57–1.55 | 0.81 |
| log (Ang-2 level), day 1 | 1.65 | 0.85–3.20 | 0.14 |
| Δ Ang-2, day 1 to 2 | 1.08 | 0.96–1.21 | 0.18 |
| Δ Ang-2, day 1 to 3 | 1.04 | 0.95–1.14 | 0.41 |
| log (SP-D level), day 1 | 1.52 | 1.03–2.24 | 0.03 |
| Δ SP-D, day 1 to 2 | 0.96 | 0.91–1.02 | 0.23 |
| Δ SP-D, day 1 to 3 | 0.96 | 0.91–1.02 | 0.21 |
Ang-2 = angiopoietin-2, OR = odds ratio, SP-D = surfactant protein-D, sRAGE = soluble receptor for advanced glycation end-products.
aEach logistic regression model for acute respiratory distress syndrome development adjusts for age (continuous), sex (male or female), race (Black, White, or other), and primary source of infection (COVID-19, pulmonary infection [pneumonia or aspiration pneumonia], or other [all other sources of infection]), in addition to the biomarker-related variable in that row.
bEach logistic regression model for mortality adjusts for age (continuous), sex (male or female), race (Black, White, or other), and vasopressor use (yes or no), in addition to the biomarker-related variable in that row.
Each row of the table represents separate logistic regression models, each adjusting for the biomarker-related variable in that row only, plus the covariates detailed below. Only the results for the biomarker-related variable from each model is presented in the table.