. 2022 Oct 21;12:17723. doi: 10.1038/s41598-022-22859-w

Table 2.

Comparison of ART outcomes in all performed cycles.

	Overall	NR	POSEIDON				p
	Overall	NR	1	2	3	4	p
No. cycles	374	124	53	77	36	84
Total FSH per cycle^b (IU)	4800.00 [450.00, 25,950.00]	3862.50 [1425.00, 10,050.00]	4500.00 [1650.00, 9750.00]	5400.00 [2100.00, 11,250.00]	6300.00 [2250.00, 25,950.00]	5850.00 [450.00, 19,050.00]	0.000
Total oocytes retrieved^b	6.00 [1.00, 52.00]	15.00 [10.00, 52.00]	5.00 [1.00, 11.00]	5.00 [1.00, 12.00]	2.00 [1.00, 14.00]	2.00 [1.00, 29.00]	0.000
GV^b	0.00 [0.00, 8.00]	1.00 [0.00, 8.00]	0.00 [0.00, 4.00]	0.00 [0.00, 3.00]	0.00 [0.00, 2.00]	0.00 [0.00, 2.00]	0.000
M1^b	0.00 [0.00, 6.00]	1.00 [0.00, 6.00]	0.00 [0.00, 5.00]	0.00 [0.00, 3.00]	1.00 [0.00, 3.00]	0.00 [0.00, 3.00]	0.000
M2^b	4.00 [0.00, 39.00]	12.00 [0.00, 39.00]	4.00 [1.00, 9.00]	3.00 [0.00, 8.00]	2.00 [0.00, 12.00]	2.00 [0.00, 25.00]	0.000
Abnormal^b	0.00 [0.00, 4.00]	0.00 [0.00, 3.00]	0.00 [0.00, 1.00]	0.00 [0.00, 2.00]	0.00 [0.00, 2.00]	0.00 [0.00, 4.00]	0.000
Total embryos^b	4.00 [1.00, 32.00]	11.00 [3.00, 32.00]	4.00 [1.00, 9.00]	3.00 [1.00, 10.00]	2.00 [1.00, 11.00]	2.00 [1.00, 23.00]	0.000
Blastocyst^b	0.00 [0.00, 13.00]	4.00 [0.00, 13.00]	0.00 [0.00, 6.00]	0.00 [0.00, 5.00]	0.00 [0.00, 6.00]	0.00 [0.00, 8.00]	0.000
Morula^a	0.77 (1.62)	0.69 (2.12)	1.09 (1.67)	1.00 (1.48)	0.47 (0.70)	0.60 (1.02)	0.037
8-cell stage^a	0.52 (1.01)	0.28 (1.08)	0.62 (1.21)	0.69 (0.98)	0.61 (0.73)	0.63 (0.83)	0.040
4-cell stage^b	0.00 [0.00, 7.00]	0.00 [0.00, 7.00]	0.00 [0.00, 2.00]	0.00 [0.00, 3.00]	0.00 [0.00, 1.00]	0.00 [0.00, 2.00]	0.011
Preg. (%)^c
Chem. preg	35 (9.4)	17 (13.7)	7 (13.2)	8 (10.4)	1 (2.8)	2 (2.4)	0.000
Clinical preg	98 (26.2)	59 (47.6)	12 (22.6)	17 (22.1)	6 (16.7)	4 (4.8)
No preg	241 (64.4)	48 (38.7)	34 (64.2)	52 (67.5)	29 (80.6)	78 (92.9)

Continuous variables are presented as either ^amean (SD) or ^bmedian [interquartile range]. Categorial variables are presented as ^cnumber of cycles (%). A p-value < 0.05 was considered statistically significant. NR normal responder, No. number, GV germinal vesicle, M1 metaphase I, M2 metaphase II, Preg. Pregnancy, Chem. Chemical, POSEIDON patient-oriented strategies encompassing individualized oocyte number.