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. 2022 Oct 21;13:6285. doi: 10.1038/s41467-022-34038-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The % antibody inhibition of ACE2 binding to RBD was determined for third dose vaccination after CC or BB prime for either B or C boost (each group n = 20 subjects) 1 month post third dose vaccination. b Heat map representation of % inhibition of 1 month post vaccination (from a). c Fold change of pre versus post booster vaccination (from a). a Data represented mean+/− stdev and individual samples. b Significant differences in paired pre versus post vaccine responses within vaccine type by one-way Friedmans tests with Dunns multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns not significant.