This cross-sectional study aimed to comprehensively investigate the association between optical coherence tomography (OCT) biomarkers and systemic inflammation in patients with diabetic macular edema (DME), which is short of research and well worth attention.

This study found that hyperreflective foci (HRF) are positively associated with systemic immune-inflammatory index (SII) in multivariable regression models, while other OCT biomarkers are not significantly related to systemic inflammation in the current study.

Systemic inflammatory markers might be helpful for DME classification and treatment decision.