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. 2022 Jun 7;19(4):1340–1352. doi: 10.1007/s13311-022-01254-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Global gene expression patterns are normalized by M₁ potentiation. Differential RNA-sequencing relative to vehicle-treated Mecp2^+/+ control mice followed by reactome pathway enrichment analysis. A Brainstem. A total of 2,141 genes were significantly disrupted in vehicle-treated Mecp2^+/- mice. Following VU595 treatment, the expression of 1,384 (64.6%) was normalized, while 757 remained disrupted. Right: pathway analysis of rescued genes. B Brainstem. Following VU595 administration, the expression of 119 genes was significantly altered in both Mecp2^+/+ and Mecp2^+/- mice. Right: pathway analysis of conserved genes. C Hippocampus. A total of 2,727 genes were significantly disrupted in vehicle-treated Mecp2^+/- mice. Following VU595 treatment, the expression of 2,294 (84.1%) was normalized, while 433 remained disrupted. Right: pathway analysis of rescued genes. D Hippocampus. Following VU595 administration, the expression of 46 genes was significantly altered in both Mecp2^+/+ and Mecp2^+/- mice. Right: pathway analysis of conserved genes