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. 2022 Apr 12;19(4):1085–1101. doi: 10.1007/s13311-022-01233-8

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022

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Fig. 4 — Classification of Human Endogenous Retrovirus-K (HERV-K): HERV-K has been classified into 11 subgroups based on sequence of the reverse transcriptase. HML-2 is the most recent insertion and the most intact retrovirus in the human genome. It has multiple insertions and based on the sequence of the envelope gene is further classified into two subtypes