Fig. 6.

Therapeutic approaches to target HERV-K (HML-2). HERV-K (HML-2) transcripts can be targeted by antisense oligonucleotides (ASO) or shRNA incorporated into adeno-associated viral vectors, extracellular Env can be targeted by monoclonal antibodies, maturation of the viral like particles can be prevented by protease inhibitors, reverse transcription of the viral transcripts to proviral DNA can be prevented by reverse transcriptase inhibitors and incorporation of the proviral DNA into the chromosome can be prevented by integrase inhibitors