Table 1.
Comparison of efficacy of antiretroviral drugs against HIV and HERV-K (HML-2)
| Antiretroviral Type | Antiretroviral Name | HIV IC90 (µM) | HIV IC50 (µM) | HERV-K (HML-2) IC90 (µM) | HERV-K (HML-2) IC50 (µM) | Note |
|---|---|---|---|---|---|---|
| RT inhibitor | Abacavir | 2.3 | 0.175 | 0.006 | tested with consensus HERV-K | |
| Zidovudine | 0.03 | 0.07 | 0.008 | |||
| AZTTP | 1 | 0.1 | 0.55 | Tested with HERV-K103 | ||
| d4TTP | 10 | 3.16 | 0.598 | |||
| 3TCTP | 3.16 | 0.316 | 0.809 | |||
| ddCTP | 3.16 | 0.316 | 0.96 | |||
| ddGTP | 0.985 | |||||
| ddTTP | 0.44 | |||||
| PRO inhibitor | Darunavir | 0.027 to 0.013 | 0.071 | 0.029 | tested with consensus HERV-K | |
| Lopinavir | 0.017 (no serum) 0.102 ( 50% serum) | 0.651 | 0.034 | |||
| IN inhibitor | Raltegravir | 0.033 | 0.075 | 0.01 |