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. 2022 May 18;19(4):1248–1258. doi: 10.1007/s13311-022-01237-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Trends across matrices (serum and plasma), analytes (NfL and pNfH), and platforms (Quanterix Simoa, Siemens Healthineers, ProteinSimple Ella, Euroimmun) of NF prior to phenoconversion. Dotted horizon lines indicate the 95th percentile for the combined control and presymptomatic carrier group. Biological samples and clinical data were from the Pre-fALS (Pre-Symptomatic Familial ALS) study