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. 2022 May 18;19(4):1248–1258. doi: 10.1007/s13311-022-01237-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Fitted neurofilament trajectory model (using Siemens Healthineers assay results) to inform the NfL threshold in ATLAS. The black curve represents the fitted model (with 95% prediction bands for the sigmoidal fit shown in gray shading), while the colored lines represent the data. The dotted horizon line indicates the predefined threshold of 44 pg/mL. Biological samples and clinical data were from the Pre-fALS (Pre-Symptomatic Familial ALS) study