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. 2022 Oct 21;13(10):891. doi: 10.1038/s41419-022-05336-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Representative images of IHC staining for CD68, CD206, and NLRP6 in primary tumors and adjacent regions in patients with SCLC. Scale bar, 100 μm. B Statistical analysis of the number of CD206⁺ TAMs in patients with and without metastatic SCLC (N = 36). C Statistical analysis of NLRP6 IHC score in CD206^high and CD206^low patients with SCLC (N = 36). D Survival analysis of patients with SCLC based on CD206 expression levels (N = 36). Bar graphs show the mean ± SEM; *P < 0.05, ***P < 0.001. TAMs tumor-associated macrophages, SCLC small cell lung cancer, IHC immunohistochemistry, SEM standard error of mean.