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. 2022 Oct 21;13(10):891. doi: 10.1038/s41419-022-05336-0

Fig. 6. SCLC-derived exosomes promote metastasis in vivo.

Fig. 6

A Flow cytometry analysis showing that SCLC-derived exosomes promote M2 macrophages switch in vivo (n = 5). Con, mice treated with PBS. Exo, mice treated with exosomes. B A schematic representation of the in vivo study design and experimental workflow. C SCLC-derived exosomes increased lung SCLC tumor number in vivo. White arrows point to the SCLC tumor site (n = 5). Con, SCLC tail vein-injected mouse models treated with PBS. Exo, SCLC tail vein-injected mouse models treated with exosomes. D Representative images of H&E staining in SCLC tumor site in different groups. E Statistical analysis of the number of visible lung tumors in different groups (n = 5). F Representative IHC images of NLRP6 and p-p65 in SCLC tumor site in different groups (n = 5). Bar graphs show the means ± SEM; **P < 0.01, ***P < 0.001. SCLC small cell lung cancer, H&E hematoxylin and eosin, IHC immunohistochemistry, SEM standard error of mean.