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. 2022 Oct 21;12:17638. doi: 10.1038/s41598-022-21576-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SLE patients show an increased frequency of circulating Tph and CXCR5⁺CD25^–Foxp3⁺ T follicular cells. Representative plots (left) and pooled data (right) of the frequency of (A) Tph cells and (B) CXCR5⁺CD25^–Foxp3⁺ T cells in the peripheral blood of HT (n = 18), RA (n = 16), and SLE (n = 32) patients, and sex- and age-matched HD (A: n = 16; B: n = 31). Each data point represents an individual subject; bars represent mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001, Kruskal–Wallis one-way analysis of variance (ANOVA) test with Dunn’s comparison post-test.