Fig. 6. Comparison of expression profile of PCPG neoplastic cells to normal fetal adrenal cell types.

a, UMAP projection illustrating snRNA-seq of fetal adrenal medulla (nSamples = 17, nCells = 10,739), previously published by Jansky et al.⁴⁹. b UMAP of PCPG cell populations colored by their cell type classification (nSamples = 30, nNeoplastic cells = 81,213, nSCLCs = 3335) and adult adrenal medulla (nSamples = 2, nChromaffin cells = 2798, nSCLCs = 143). The black dotted lines show normal chromaffin and SCLC cell types. c Proportion NEO cells or normal cells (PCPG and NAM combined) classified as normal fetal adrenal cell types. d snRNA-seq gene-module scores for NEO cells, normal chromaffin cells, and SCLCs based on the gene-sets identified by Jansky et al. (nSamples = 32, nCells = 87,489)⁴⁹. e GSVA scores using fetal adrenal gene-sets across PCPG subtypes in the PCPG bulk-tissue data. f snRNA-seq gene-expression for markers for fetal adrenal cells and PCPG subtypes in normal fetal cell data. g Expression of the same genes shown in panel (f) but in NEO cells across PCPG subtypes (NEO cells were pooled based on genotype and subtype profile). h Bulk-tissue gene-expression (n = 628 samples) for the same genes shown in panel (f, g).