Skip to main content
. 2022 Oct 12;8(10):e11022. doi: 10.1016/j.heliyon.2022.e11022

Figure 1.

Figure 1

Enrichment analysis and feature selection. Heatmap of differentially modified 5-hydroxymethylcytosine (5 hm C) gene bodies between gliomas and non-tumor samples (A). Scatterplot of enrichment analysis using DAVID database, the count in x-axis represented the genes involved in correspond terms (B). Principal component analysis (PCA) on differentially modified 5-hydroxymethylcytosine (5 hm C) gene bodies and demonstrated the first two principal components (PCA1 and PCA2) (C). LASSO regression analysis for dimensionality reduction (D). The six gene bodies were all upregulated in glioma in 5 hm C-Seal data (E). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001. Abbreviations: LGG, lower grade glioma; GBM, glioblastoma; LASSO, least absolute shrinkage and selection operator.