Diagnostic value of GDScore. Heatmap of 6 features selected in GDScore calculation. The expression values of candidate genes were normalized from −2 to 2 (A, D and G). Scatterplot of GDScore distribution among samples in the training, testing and validation sets (B, E, and H). AUC values demonstrated GDScore was a potential biomarker for early detection of glioma, GBM and LGG in the three sets (C, F and I). Abbreviations: AUC, area under curve.