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. 2022 Oct 17;85:104304. doi: 10.1016/j.ebiom.2022.104304

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Overview of modifications differentiating second-geneneration miR-29 from first gen MRG-201/Remlarsen. Top, first-gen MRG-201, the parent compound, bottom, MRG-229 (Next generation miR-29 mimic), the second-gen compound. DNA bases: white circles = unmodified base, blue circles = 2’OMe, purple circles = 2’F, linkages: green circles = phosphorodiester linkage, orange circles = phosphorothioate (PS) linkage. NH2 terminus modification: MRG-201/Remlarsen = cholesterol, BiPPB = platelet-derived growth factor beta receptor (PDGFβR)-binding peptide (BiPPB).