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. 2022 Oct 21;12:17665. doi: 10.1038/s41598-022-21617-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of differentially expressed (DE) genes. (A) Genes were considered detectable if there were > 1.5 counts per million in > 3 samples out of all samples from the same cell line. (B) Genes that were DE between starved and control samples in at least one cell line. (C) Genes that were DE between mTOR inhibited and control samples in at least one cell line. (D) We collected DE genes associated with starvation or mTOR inhibition that were up-regulated in at least one cell line (inconsistent DE genes that were significantly up-regulated in one cell line but significantly down-regulated in another were excluded). (E) Down-regulated DE genes associated with starvation or mTOR inhibition.