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. 2022 Oct 21;12:17665. doi: 10.1038/s41598-022-21617-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Top 25 differentially expressed (DE) genes based on the maximum FDR rule. Genes mentioned in the main text are highlighted for easier visual localization. (A) Genes were sorted according to the maximum FDR-adjusted P-value across six experiments. Discordant genes that were significantly (P_FDR < 5%) up-regulated in one and down-regulated in another experiment were excluded. (B) Genes were sorted according to the maximum P_FDR across all starvation experiments. We also required that all starvation responses were directionally concordant and that the mean log₂ fold change across mTOR experiments was in the opposite direction. (C) Genes were sorted according to the maximum P_FDR across all mTOR inhibition experiments. We required that all mTOR inhibition responses were directionally concordant and that the mean log₂ fold change across starvation experiments was in the opposite direction. (D) Genes were sorted according to the maximum P_FDR across responses in the SH-SY5Y cells. Missing signals were set to zero log₂ fold change in other cell lines. We also required that the mean log₂ fold changes in other cells were in the opposite direction to SH-SY5Y responses.