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. 2022 Oct 21;12:17665. doi: 10.1038/s41598-022-21617-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of differentially expressed genes in the Kyoto Encyclopedia of Genes and Genomes pathway repository. (A) Over-representation analysis of DE genes. Pathways that produced a significant signal (P_FDR < 0.05) in at least one experiment are shown. (B) Normalized perturbation scores from Signaling Pathway Impact Analysis. A negative (positive) score implies that the aggregate impact of DE genes is likely to decrease (increase) the activity of a pathway. Pathways that were directionally concordant (all significant signals in the same direction) and that produced at least three significant signals (P_FDR < 0.05) are included.