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. 2022 Sep 9;63(10):100275. doi: 10.1016/j.jlr.2022.100275

Table 2.

Fecal BA concentrations in by age groups obtained by Methods A and B

(μmol/g) 6–11 months (N=6)
 1 year (N=6)
 2 years (N=7)
 3 years (N=7)
 4 years (N=7)
 5–7 years (N=7)
 9–12 years (N=6)
 19–22 years (N=14)
 37–71 years (N=4)
Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD
TBA (Method A) 14.72 ± 13.31 16.90 ± 8.01 20.14 ± 27.21 14.32 ± 8.07 9.50 ± 5.87 24.23 ± 17.19 21.80 ± 9.48 20.04 ± 13.17 30.72 ± 21.87
TBA (Method B) 14.77 ± 12.62 17.46 ± 8.00 23.81 ± 26.99 16.56 ± 9.26 12.83 ± 7.11 30.03 ± 18.88 30.62 ± 11.17 28.02 ± 12.83 35.11 ± 23.15
CA (Method A) 6.86 ± 7.88 8.58 ± 5.54 5.26 ± 11.45 2.17 ± 1.91 0.40 ± 0.64 3.40 ± 7.10 0.17 ± 0.23 2.72 ± 3.91 1.06 ± 1.66
CA (Method B) 6.66 ± 7.60 8.52 ± 5.69 5.63 ± 12.04 2.25 ± 1.80 0.51 ± 0.75 3.58 ± 7.02 0.59 ± 0.45 3.13 ± 4.08 1.08 ± 1.58
CDCA (Method A) 2.87 ± 3.60 2.79 ± 1.98 4.62 ± 9.95 0.64 ± 0.57 0.16 ± 0.16 0.84 ± 1.43 0.14 ± 0.15 1.13 ± 1.26 0.52 ± 0.54
CDCA (Method B) 2.88 ± 3.52 2.86 ± 2.06 4.95 ± 10.55 0.75 ± 0.58 0.22 ± 0.17 1.04 ± 1.54 0.43 ± 0.32 1.43 ± 1.31 0.64 ± 0.66
UDCA (Method A) 0.24 ± 0.50 0.63 ± 0.40 2.29 ± 3.61 0.88 ± 0.70 0.31 ± 0.35 1.42 ± 2.71 0.23 ± 0.20 1.18 ± 1.39 1.08 ± 1.06
UDCA (Method B) 0.24 ± 0.51 0.66 ± 0.42 2.47 ± 3.87 0.97 ± 0.78 0.38 ± 0.35 1.52 ± 2.77 0.48 ± 0.38 1.43 ± 1.53 1.16 ± 1.16
DCA (Method A) 0.00 ± 0.00 0.04 ± 0.08 2.19 ± 2.76 2.85 ± 3.99 3.00 ± 2.90 6.06 ± 5.96 8.92 ± 5.22 3.10 ± 2.53 12.77 ± 9.58
DCA (Method B) 0.00 ± 0.00 0.04 ± 0.09 2.39 ± 2.91 3.00 ± 4.11 3.01 ± 2.75 7.95 ± 7.47 12.28 ± 5.59 4.73 ± 3.79 14.47 ± 10.29
LCA (Method A) 0.00 ± 0.00 0.00 ± 0.01 0.94 ± 0.70 1.27 ± 1.45 1.40 ± 1.01 2.85 ± 2.79 5.26 ± 2.75 1.85 ± 1.67 3.80 ± 2.51
LCA (Method B) 0.00 ± 0.00 0.01 ± 0.01 1.00 ± 0.74 1.40 ± 1.59 1.44 ± 0.99 3.19 ± 3.29 5.62 ± 3.01 2.08 ± 1.83 4.42 ± 3.27
UCA (Method A) 0.46 ± 0.93 1.50 ± 1.59 1.00 ± 1.43 1.91 ± 3.31 0.67 ± 1.16 1.73 ± 3.32 0.14 ± 0.09 2.30 ± 5.00 0.50 ± 0.45
UCA (Method B) 0.45 ± 0.93 1.53 ± 1.59 1.11 ± 1.51 1.94 ± 3.30 0.70 ± 1.21 1.95 ± 3.30 0.35 ± 0.20 2.97 ± 5.81 0.53 ± 0.48
12β-OH-LCA (Method A) 0.00 ± 0.00 0.01 ± 0.02 0.26 ± 0.24 0.31 ± 0.47 0.43 ± 0.44 2.10 ± 2.85 1.45 ± 1.29 0.68 ± 0.78 2.01 ± 2.22
12β-OH-LCA (Method B) 0.00 ± 0.00 0.01 ± 0.02 0.26 ± 0.24 0.33 ± 0.51 0.41 ± 0.42 2.15 ± 2.88 1.53 ± 1.30 0.77 ± 0.77 2.08 ± 2.35
12-oxo-LCA (Method A) 0.00 ± 0.00 0.00 ± 0.01 0.18 ± 0.12 0.43 ± 0.61 0.83 ± 0.99 1.07 ± 1.32 1.84 ± 0.95 2.23 ± 2.85 1.43 ± 0.80
12-oxo-LCA (Method B) 0.00 ± 0.00 0.00 ± 0.01 0.19 ± 0.12 0.46 ± 0.67 0.80 ± 0.90 1.11 ± 1.36 1.89 ± 1.01 2.26 ± 2.74 1.48 ± 0.88
isoCA (Method A) 0.05 ± 0.05 0.28 ± 0.42 0.08 ± 0.12 0.21 ± 0.19 0.03 ± 0.04 0.20 ± 0.38 0.01 ± 0.02 0.29 ± 0.45 0.14 ± 0.22
isoCA (Method B) 0.06 ± 0.05 0.30 ± 0.41 0.11 ± 0.11 0.26 ± 0.22 0.07 ± 0.06 0.25 ± 0.43 0.08 ± 0.04 0.36 ± 0.47 0.15 ± 0.20
isoCDCA (Method A) 0.02 ± 0.03 0.17 ± 0.25 0.13 ± 0.17 0.09 ± 0.08 0.03 ± 0.03 0.09 ± 0.14 0.01 ± 0.01 0.15 ± 0.18 0.05 ± 0.04
isoCDCA (Method B) 0.26 ± 0.46 0.45 ± 0.33 0.64 ± 0.33 0.76 ± 0.91 0.44 ± 0.21 0.56 ± 0.37 0.71 ± 0.42 0.70 ± 0.27 0.10 ± 0.04
isoUDCA (Method A) 0.04 ± 0.09 0.05 ± 0.09 0.17 ± 0.33 0.23 ± 0.19 0.06 ± 0.06 0.23 ± 0.36 0.06 ± 0.05 0.25 ± 0.32 0.26 ± 0.29
isoUDCA (Method B) 0.05 ± 0.12 0.20 ± 0.34 0.43 ± 0.31 0.76 ± 0.86 0.30 ± 0.16 0.34 ± 0.42 0.44 ± 0.31 0.63 ± 0.38 0.31 ± 0.31
isoDCA (Method A) 0.00 ± 0.00 0.00 ± 0.00 0.20 ± 0.24 0.37 ± 0.59 0.24 ± 0.26 0.51 ± 0.46 0.69 ± 0.39 0.31 ± 0.22 1.44 ± 1.08
isoDCA (Method B) 0.00 ± 0.00 0.03 ± 0.06 1.10 ± 1.01 0.60 ± 0.79 1.53 ± 1.33 1.33 ± 0.92 1.97 ± 0.54 2.22 ± 1.65 2.21 ± 1.01
isoLCA (Method A) 0.00 ± 0.00 0.00 ± 0.00 0.21 ± 0.18 0.29 ± 0.34 0.27 ± 0.20 0.58 ± 0.58 0.93 ± 0.41 0.41 ± 0.39 0.75 ± 0.65
isoLCA (Method B) 0.00 ± 0.00 0.00 ± 0.01 0.64 ± 0.63 0.39 ± 0.45 1.03 ± 0.85 1.50 ± 1.75 1.75 ± 0.59 1.94 ± 1.85 1.31 ± 0.88
isoUCA (Method A) 0.05 ± 0.12 0.11 ± 0.23 0.14 ± 0.20 0.44 ± 0.64 0.10 ± 0.15 0.27 ± 0.36 0.05 ± 0.05 0.44 ± 0.96 0.18 ± 0.16
isoUCA (Method B) 0.05 ± 0.12 0.11 ± 0.24 0.15 ± 0.21 0.44 ± 0.63 0.10 ± 0.15 0.28 ± 0.38 0.06 ± 0.06 0.47 ± 1.03 0.18 ± 0.16
12β-OH-isoLCA (Method A) 0.00 ± 0.00 0.00 ± 0.00 0.01 ± 0.03 0.02 ± 0.03 0.02 ± 0.02 0.10 ± 0.10 0.09 ± 0.08 0.05 ± 0.05 0.16 ± 0.17
12β-OH-isoLCA (Method B) 0.00 ± 0.00 0.00 ± 0.00 0.12 ± 0.15 0.02 ± 0.04 0.09 ± 0.10 0.20 ± 0.19 0.17 ± 0.12 0.25 ± 0.26 0.32 ± 0.22
12-oxo-isoLCA (Method A) 0.00 ± 0.00 0.00 ± 0.00 0.07 ± 0.05 0.12 ± 0.16 0.17 ± 0.18 0.20 ± 0.20 0.30 ± 0.15 0.32 ± 0.33 0.34 ± 0.19
12-oxo-isoLCA (Method B) 0.00 ± 0.00 0.00 ± 0.01 0.28 ± 0.25 0.16 ± 0.19 0.56 ± 0.67 0.42 ± 0.39 0.65 ± 0.37 0.93 ± 0.75 0.49 ± 0.08
oxo-BAsa (Method A) 1.89 ± 1.74 1.68 ± 1.52 0.90 ± 1.14 1.44 ± 0.35 0.74 ± 0.31 1.24 ± 1.29 0.87 ± 0.57 2.14 ± 1.12 1.01 ± 0.77
oxo-BAsa (Method B) 1.72 ± 1.70 1.61 ± 1.45 0.77 ± 1.07 1.13 ± 0.24 0.49 ± 0.23 1.11 ± 1.27 0.54 ± 0.41 1.03 ± 0.93 0.60 ± 0.63
3-oxo-Δ4-BAsb (Method A) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.01 ± 0.02 0.00 ± 0.01 0.01 ± 0.02 0.00 ± 0.00 0.02 ± 0.03 0.00 ± 0.00
3-oxo-Δ4-BAsb (Method B) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.01 ± 0.02 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
BA-3Sc (Method A) 1.52 ± 1.12 0.60 ± 0.68 0.58 ± 1.34 0.19 ± 0.47 0.48 ± 1.18 0.75 ± 1.13 0.46 ± 1.03 0.11 ± 0.36 2.59 ± 1.66
BA-3Sc (Method B) 1.60 ± 1.17 0.63 ± 0.67 0.70 ± 1.57 0.23 ± 0.56 0.44 ± 1.09 0.75 ± 1.13 0.45 ± 1.01 0.15 ± 0.43 2.83 ± 1.78
others (Method A) 0.70 ± 0.32 0.46 ± 0.22 0.89 ± 1.81 0.47 ± 0.59 0.15 ± 0.11 0.61 ± 0.90 0.19 ± 0.16 0.39 ± 0.50 0.63 ± 0.63
others (Method B) 0.80 ± 0.28 0.50 ± 0.20 0.88 ± 1.46 0.71 ± 0.66 0.30 ± 0.15 0.80 ± 0.83 0.66 ± 0.38 0.53 ± 0.39 0.76 ± 0.55

Abbreviations of each BA are shown in Supplemental Table 1.

SD, standard deviation; 3S, 3-sulfate; Unit: μmol/g; Values are expressed as mean ± SD.

a

oxo-BAs is the sum of 3-oxo-CA, 3-oxo-CDCA, 3-oxo-UDCA, 3-oxo-DCA, 3-oxo-LCA, 7-oxo-DCA, 12-oxo-CDCA, 7-oxo-LCA, 3-oxo-alloCDCA, 3-oxo-alloDCA, and 3-oxo-alloLCA.

b

3-oxo-Δ4-BAs is the sum of CA-Δ4-3-one, GCA-Δ4-3-one, TCA-Δ4-3-one, CDCA-Δ4-3-one, GCDCA-Δ4-3-one, TCDCA-Δ4-3-one, CA-Δ4,6-3-one, and CDCA-Δ4,6-3-one.

c

BA-3S is the sum of CA-3S, GCA-3S, TCA-3S, C CDCA-3S, GCDCA-3S, TCDCA-3S, UDCA-3S, GUDCA-3S, TUDCA-3S, DCA-3S, GDCA-3S, TDCA-3S, LCA-3S, GLCA-3S, and TLCA-3S.