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Tie2 agonists stabilize cellular junctions. (a) Immunofluorescence imaging of HUVEC cells treated with 100 ng/mL of Ang-1 or 10 µg/mL of Tie2.1-hexamer for 3 hours and stained with DAPI (blue) or anti-Tie2 (green). (b) Tie2 agonists drove relocalization to cell–cell contacts. HUVEC cells treated as above or with 10 µg/mL of Tie.1.38 Fab-IgG were stained with DAPI (blue), anti-VE-cadherin (red), or phalloidin (green) and analyzed by fluorescent microscopy.
