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. 2022 Oct 22;26:58. doi: 10.1186/s40824-022-00298-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Schematic fabrication procedure of rmDPPs. (a) The inverse of the Si master template is acquired by pouring the polydimethylsiloxane (PDMS) solution into the master template. (b) A poly(vinyl alcohol (PVA) film with the same structure as the master template is made by pouring PVA solution into the PDMS template. (c) Filling the discoidal wells with a polymer paste obtained from poly(lactic-co-glycolic) acid (PLGA), SPIONs, and rtPA. (d) The hydrophilic layer of the PVA mask is dissolved in water, and (e) flow through membranes with 100 and 1.2 $μ$ m-sized pores is performed to purify the rmDPPs. (f) Schematic illustration of rmDPPs consisting of PLGA, SPIONs, and rtPA in a blood vessel