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. 2022 Oct 21;16:47. doi: 10.1186/s40246-022-00422-y

Table 2.

Genome-wide significant associations with eGFR, DKD, and DKD meta-analysis

P value OR (95% CI) Beta (95% CI)
SNP CHR BP Gene A1 A2 MAF DKD eGFR (T2D) eGFR (non-diabetic) DKD Meta-analysis DKD DKD Meta-analysis eGFR (T2D) eGFR (non-diabetic)
rs12917707 16 20,367,690 UMOD T G 0.18 1.17E−09 1.31E−15 1.54E−72 4.45E−08 0.80 (0.75, 0.86) 0.8566 (0.81, 0.9) 1.22 (0.9, 1.5) 0.77 (0.7, 0.84)
rs13333226 16 20,365,654 UMOD G A 0.19 3.27E−09 7.29E−15 8.96E−73 NS 0.81 (0.75, 0.87) 1.18 (0.88, 1.47) 0.77 (0.7, 0.84)
rs4293393 16 20,364,588 UMOD G A 0.18 5.15E−09 1.71E−14 3.96E−73 NS 0.81 (0.76, 0.87) 1.16 (0.86, 1.45) 0.77 (0.7, 0.84)
rs7185940 16 20,410,488 PDILT A G 0.28 5.36E−08 1.79E−12 1.45E−33 NS 0.84 (0.8, 0.9) 0.92 (0.66, 1.71) 0.44 (0.38, 0.5)
rs7192797 16 20,411,763 PDILT A G 0.28 7.66E−08 4.58E−12 1.10E−33 NS 0.85 (0.8, 0.9) 0.9 (0.64, 1.1) 0.44 (0.38, 0.5)
rs9926580 16 20,410,547 PDILT T C 0.28 6.61E−08 7.68E−12 3.86E−34 NS 0.85 (0.8, 0.9) 0.89 (0.63, 1.1) 0.45 (0.39, 0.5)
rs11864909 16 20,400,839 PDILT T C 0.29 NS 1.35E−13 6.12E−45 NS 0.95 (0.7, 1.2) 0.51 (0.45, 0.47)
rs35208507 16 20,388,929 PDILT G A 0.31 NS 2.65E−12 5.26E−40 NS 0.88 (0.63, 1.13) 0.88 (0.41, 0.52)
rs4321205 16 20,375,536 PDILT T C 0.38 NS 8.23E−11 1.65E−30 NS 0.78 (0.54, 1) 0.39 (0.33, 0.44)
rs7805747 7 151,407,801 PRKAG2 A G 0.27 NS 2.79E−10 5.07E−72 NS − 0.83 (− 1.09, − 0.57) − 0.66 (− 0.72, − 0.61)
rs72763500 1 236,116,561 NID1 C T NS NS NS 2.58E−08 0.7933 (0.73, 0.85)

Italics indicates that the significant P value ≤ 5 × 10−8

CHR: Chromosome; BP: SNP position (Build 37); A1: minor allele; A2: reference allele; MAF: minor allele frequency; DKD: diabetic kidney disease; eGFR: estimated glomerular filtration rate; and OR: odd ratio