Table 4.

Subgroup analyses overview

Objective	Outcome		Hypothesis	Method of analysis
	Name	Type
Subgroup Analysis 1
Males versus females	PPSP as defined by the WHO, and of ≥ 4/10 severity	Binary	CBT will be associated with a larger reduction in the prevalence of PPSP in females compared to males	Logistic regression
Subgroup Analysis 2
Any open fracture versus no open fracture	PPSP as defined by the WHO, and of ≥ 4/10 severity	Binary	CBT will be associated with a larger reduction in the prevalence of PPSP in participants with open fractures compared to participants with only closed fractures	Logistic regression
Subgroup Analysis 3
Military, veteran, and first responders versus other patients	PPSP as defined by the WHO, and of ≥ 4/10 severity	Binary	CBT will be associated with a larger reduction in the prevalence of PPSP in participants who are employed by the military, veterans, or first responders	Logistic regression
Subgroup Analysis 4
Higher versus lower SPOC scores	PPSP as defined by the WHO, and of ≥ 4/10 severity	Binary	CBT will be associated with a larger reduction in the prevalence of PPSP in participants with higher vs. lower SPOC scores	Logistic regression

PPSP Persistent post-surgical pain