Table 2.

In vitro antiplasmodial activity in P. falciparum cultures of amyloid pan-inhibitors and β-sheet intercalators

Compound	Chemical family	IC50 in 3D7 strain (µM) ± SEM	IC50 in K1 strain (µM) ± SEM	Selectivity index in vitro1
HUP5ANTRAa	Aminoquinoline	0.78 ± 1.86	N/D	97.7
HUP7ANTRAa	Aminoquinoline	7.53 ± 0.84	N/D	3.9
HUP10ANTRAa	Aminoquinoline	8.73 ± 1.61	N/D	9.7
HUP7TH	Aminoquinoline	0.13 ± 0.01	0.47 ± 0.36b	60.0
HUP8TH	Aminoquinoline	0.21 ± 0.01	0.39 ± 0.14b	23.3
HUP9TH	Aminoquinoline	0.16 ± 0.02	0.35 ± 0.06b	30.6
HUPH10TH	Aminoquinoline	0.18 ± 0.05	3.50 ± 2.29b	18.9
HUPNTH	Aminoquinoline	0.31 ± 0.02	0.43 ± 0.22b	11.0
HUPNTCl	Aminoquinoline	0.15 ± 0.01	0.52 ± 0.13b	42.0
DP128c	Aminoquinoline	0.65 ± 0.14	N/D	75.4
DONE3TCl	Aminoquinoline	0.08 ± 0.03	0.36 ± 0.07c	157.5
YAT2150	Bis(styrylpyridinium) salt	0.09 ± 0.02	N/D	37.8
ThT	Benzothiazolium salt	1.57 ± 0.23	N/D	N/D
Congo Red	Bis(naphthalenesulfonate)	> 15	N/D	N/D

¹50% cytotoxic concentration (CC₅₀)/IC₅₀ in 3D7 strain. See Additional file 1: Table S9 for CC₅₀ values

^a[57]

^b[39]

^c[40]

N/D no data