Table 3.
Top SNPs with P Values at Least 10−7 Levels Identified by Genotyping
| SNP | Gene | Location | Chr: Position | Allele | Minor Allele Freq. | Unadjusted P value | Unadjusted | Adjusteda | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | ORs | 95% CI | ORs | 95% CI | ||||||||
| rs1008982 | MGMT | Intron | 10: 131445731 | G/A | 0.560 | 0.290 | 1.36 × 10−10 | 3.12 | 2.19 | 4.46 | 4.55 | 2.81 | 7.35 |
| rs12266634 | MGMT | Intron | 10: 131412659 | G/C | 0.512 | 0.267 | 2.76 × 10−9 | 2.88 | 2.02 | 4.12 | 3.78 | 2.40 | 5.95 |
| rs1711667 | MGMT | Intron | 10: 131278410 | C/A | 0.590 | 0.357 | 7.52 × 10−8 | 2.60 | 1.82 | 3.70 | 3.47 | 2.23 | 5.37 |
| rs10466114 | MGMT | Intron | 10: 131367368 | A/G | 0.458 | 0.253 | 3.84 × 10−7 | 2.50 | 1.74 | 3.58 | 2.95 | 1.94 | 4.49 |
| rs1549102 | ANKS1B | Intron | 12: 99282746 | C/A | 0.663 | 0.438 | 3.62 × 10−7 | 2.52 | 1.75 | 3.62 | 2.50 | 1.71 | 3.66 |
Abbreviations: CI, confidence interval; OR, odds ratio.
aAdjusting for the selected clinical risk factors: treatment arm, gender, and anticonvulsants.