Table 4.
Association between Haplotypes in MGMT and Myelotoxicity
| Blocks | Haplotypea | Cases (N=83) | Controls (N=284) | Total % | ORb | 95% Wald CI | Global P-value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | |||||||
| Block 1 | AG | 32 | 38.8 | 182 | 64.0 | 58.4 | 1.00 | <.0001 | ||
| CA | 36 | 43.6 | 70 | 24.8 | 29.1 | 3.96 | 2.45 | 6.40 | ||
| CG | 13 | 15.5 | 31 | 10.8 | 11.8 | 2.98 | 1.62 | 5.49 | ||
| Block 2 | CA | 34 | 40.7 | 197 | 69.5 | 63.0 | 1 | <.0001 | ||
| GG | 40 | 47.9 | 71 | 24.9 | 30.1 | 4.98 | 2.99 | 8.29 | ||
| Block free | AGCA | 30 | 36.0 | 178 | 62.8 | 56.7 | 1 | <.0001 | ||
| CAGG | 32 | 39.0 | 56 | 19.7 | 24.2 | 6.40 | 3.59 | 11.43 | ||
Note: Loci for Block 1: rs1711667 and rs10466114; Block 2: rs12266634 and rs1008982; block free: rs1711667, rs10466114, rs12266634, and rs1008982.
aHaplotypes with frequency less than 0.05 were excluded from the analysis.
bLogistic regression model adjusting for treatment arm, gender, and anticonvulsant use.