TABLE 6.
Comparison of between-laboratory precision in absolute T-cell counts for predicate method versus Flow-Count methoda
T cells | CD4 stratum (cells/μl) | Median %CV (P vs predicate method)
|
|
---|---|---|---|
Predicate method | Flow-Count method | ||
CD4 | All | 18.2 | 10.8 (0.000) |
<200 | 19.5 | 12.0 (0.000) | |
200–500 | 16.7 | 9.4 (0.007) | |
>500 | 18.8 | 12.1 (0.055) | |
CD8 | All | 16.9 | 10.1 (0.000) |
<200 | 18.1 | 10.8 (0.000) | |
200–500 | 15.5 | 7.9 (0.002) | |
>500 | 17.2 | 10.8 (0.098) |
%CVs were calculated from the same specimens analyzed by both methods in all five laboratories. %CV by the predicate method was compared with %CV by the test method as described in Materials and Methods. A P value of <0.025 was considered significant.