Table 2.

Factors Associated with Central Obesity in Univariable and Multivariable Analyses (Logistic Regression, ANRS CO22 Hepather Cohort, n=3706)

Variables	Univariable analysis (n=3706), OR [95% CI]	p	Multivariable analysis (n=3587), aOR [95% CI]	p
Cannabis use
Never (Ref.)	1	<10−3	1	0.002
Former	0.80 [0.57–1.14]	0.220	1.20 [0.84–1.72]	0.322
Current	0.23 [0.13–0.38]	<10−3	0.41 [0.24–0.70]	0.001
Gender
Male (Ref.)	1		1
Female	2.58 [2.25–2.96]	<10−3	2.92 [2.51–3.40]	<10−3
Age at baseline, years	1.04 [1.03–1.05]	<10−3	1.05 [1.04–1.05]	<10−3
Coffee consumption
0 cup/day (Ref.)	1	0.076
1–2 cups/day	1.12 [0.97–1.31]	0.129
≥3 cups/day	1.20 [1.02–1.42]	0.028
Tobacco smoking
Never (Ref.)	1	<10−3
Former	1.33 [1.12–1.59]	0.002
Current	0.72 [0.60–0.85]	<10−3
Alcohol consumption
Abstinent without past unhealthy use (Ref.)	1	0.002
Abstinent with past unhealthy use	1.54 [1.09–2.18]	0.015
Moderate use	0.89 [0.78–1.02]	0.096
Unhealthy use	1.82 [1.05–3.17]	0.033
Living in poverty
No (Ref.)	1		1
Yes	1.28 [1.12–1.45]	<10−3	1.47 [1.26–1.70]	<10−3
Education level
< Secondary school diploma (Ref.)	1		1
≥ Secondary school diploma	0.63 [0.55–0.72]	<10−3	0.83 [0.72–0.96]	0.013
Employed
No (Ref.)	1
Yes	0.68 [0.59–0.77]	<10−3
Advanced liver fibrosisa
No (Ref.)	1
Yes	1.30 [0.94–1.81]	0.113
Time since HBV diagnosis, years	1.02 [1.01–1.02]	<10−3
HBV treatment status
Never treated (Ref.)	1	0.282
History of treatment	1.14 [0.86–1.50]	0.369
Ongoing treatment	0.93 [0.81–1.06]	0.275

Central obesity was defined as having a waist circumference ≥94 cm for men (except for men born in Asia, Central, or South America, for whom the cutoff was set at 90 cm) and ≥80 cm for women.²⁵

^a Advanced liver fibrosis was defined as a FIB-4 score >3.25.³¹

aOR, adjusted odds ratio; CI, confidence interval; OR, odds ratio.