Table 3.

Factors Associated with Overweight and Obesity in Univariable Analyses (Multinomial Logistic Regression, ANRS CO22 Hepather Cohort, n=3706)

Variables	Overweight (25 ≤ BMI <30), RRR [95% CI]	p	Obesity (BMI ≥30), RRR [95% CI]	p
Cannabis use
Never (Ref.)	1	0.006	1	0.005
Former	0.99 [0.67–1.44]	0.941	1.07 [0.65–1.77]	0.786
Current	0.46 [0.29–0.74]	0.001	0.09 [0.02–0.39]	0.001
Gender
Male (Ref.)	1		1
Female	0.71 [0.61–0.83]	<10−3	1.60 [1.32–1.94]	<10−3
Age at baseline, years	1.02 [1.01–1.02]	<10−3	1.03 [1.02–1.03]	<10−3
Coffee consumption
0 cup/day (Ref.)	1	0.057	1	0.509
1–2 cups/day	1.05 [0.89–1.24]	0.552	1.04 [0.83–1.31]	0.713
≥3 cups/day	1.24 [1.03–1.48]	0.020	1.15 [0.90–1.48]	0.250
Tobacco smoking
Never (Ref.)	1	<10−3	1	<10−3
Former	1.46 [1.20–1.77]	<10−3	1.42 [1.10–1.83]	0.006
Current	0.93 [0.77–1.13]	0.477	0.64 [0.48–0.85]	0.002
Alcohol consumption
Abstinent without past unhealthy use (Ref.)	1	0.182	1	0.002
Abstinent with past unhealthy use	1.48 [1.00–2.18]	0.048	2.29 [1.46–3.60]	<10−3
Moderate use	1.09 [0.94–1.26]	0.261	1.08 [0.88–1.33]	0.446
Unhealthy use	1.23 [0.68–2.23]	0.498	1.68 [0.82–3.46]	0.158
Living in poverty
No (Ref.)	1		1
Yes	1.16 [1.00–1.34]	0.047	1.66 [1.37–2.02]	<10−3
Education level
< Secondary school diploma (Ref.)	1		1
> Secondary school diploma	0.84 [0.73–0.97]	0.018	0.53 [0.43–0.64]	<10−3
Employed
No (Ref.)	1		1
Yes	0.97 [0.83–1.12]	0.631	0.64 [0.53–0.78]	<10−3
Advanced liver fibrosisa
No (Ref.)	1		1
Yes	0.86 [0.59–1.24]	0.416	1.19 [0.76–1.87]	0.438
Time since HBV diagnosis, years	1.01 [1.00–1.01]	0.189	1.00 [0.99–1.01]	0.727
HBV treatment status
Never treated (Ref.)	1	0.264	1	0.254
History of treatment	0.88 [0.65–1.20]	0.429	0.68 [0.43–1.08]	0.101
Ongoing treatment	0.89 [0.77–1.03]	0.117	0.95 [0.78–1.15]	0.586

Bold values highlight the global p-value for variables with more than 2 modalities.

^a Advanced liver fibrosis was defined as a FIB-4 score >3.25.³¹

RRR, relative risk ratio.