Table 1.

Summary of Retinal Ganglion Cell Dendritic Changes by Retinal Ganglion Cell Subtype in Glaucoma/Elevated Intraocular Pressure

RGC type	Species	Reference	IOP model	labeling approach	Sholl intersections	Dendritic field area	Total dendritic length
αOn-sus	Mouse	Ou et al. (116)	Laser	Biolistic	Reduced	No change
	Mouse	Bhandari et al. (16)	Microbead	Patch clamp dye fill	Reduced		Reduced
	Mouse	Risner et al. (134)	Microbead	Patch clamp dye fill	Reduced	Reduced	Reduced
	Mouse	Feng et al. (46)	Laser	SMI-32 Immunostaining		Reduced
αOff-trans	Mouse	El-Danaf and Huberman (43)	Microbead	Sharp electrode dye fill	Reduced	Reduced	Reduced
	Mouse	Ou et al. (116)	Laser	Biolistic	Reduced	Reduced
	Mouse	Risner et al. (134)	Microbead	Patch clamp dye fill	Reduced	Reduced	Reduced
aOff-sus.	Mouse	Ou et al. (116)	Laser	Biolistic	Reduced	Reduced
	Mouse	Risner et al. (134)	microbead	Patch clamp dye fill	No change	No change	No change
ooDSGC (On dendrites)	Mouse	El-Danaf and Huberman (43)	Microbead	Sharp electrode dye fill	Increased	No change	Increased
	Mouse	Ou et al. (116)	Laser	Biolistic	No change
	Mouse	Risner et al. (134)	Microbead	Patch clamp dye fill	Reduced	Reduced	Reduced
	Mouse	Risner et al. (134)	10-month DBA/2J	Patch clamp dye fill	Reduced	Reduced	Reduced
ooDSGC (Off dendrites)	Mouse	El-Danaf and Huberman (43)	Microbead	Sharp electrode dye fill	No change	No change	Reduced
	Mouse	Ou et al. (116)	Laser	Biolistic	Reduced
	Mouse	Risner et al. (134)	Microbead	Patch clamp dye fill	No change	No change	No change
On DSGC	Mouse	El-Danaf and Huberman (43)	Microbead	Sharp electrode dye fill	No change	No change	No change
M1 ipRGC	Mouse	El-Danaf and Huberman (43)	Microbead	Sharp electrode dye fill	Reduced	No change	Reduced
	Rat	Li et al. (94)	Laser	Melanopsin immunofluorescence	No change
On	Mouse	Risner et al. (134)	10-month DBA/2J	Patch clamp dye fill	Reduced	Reduced	Reduced
Off	Mouse	Risner et al. (134)	10-month DBA/2J	Patch clamp dye fill	Reduced	Reduced	Reduced
On-Off	Mouse	Risner et al. (134)	10-month DBA/2J	Patch clamp dye fill	Reduced	Reduced	Reduced
	Mouse	Feng et al. (46)	Laser	Thy1-YFP
Midget	Human	Tribble et al. (157)	Human patient tissue	Serial block face scanning EM	Reduced number and length of dendrites
	Rhesus macaque	Weber et al. (172)	TM lasering	Sharp electrode fill		Reduced (severe glaucoma)
Parasol	Rhesus macaque	Weber et al. (172)	TM lasering	Sharp electrode fill		Reduced

Dendritic changes are determined from the authors' descriptions and data figures.

IOP, intraocular pressure; M1 ipRGC, M1-type melanopsin-expressing intrinsically photosensitive retinal ganglion cell; RGC, retinal ganglion cell; sus, sustained; trans, transient; ooDSGC, On-Off direction-selective retinal ganglion cell; YFP, Yellow fluorescent protein.