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. 2022 Oct 12;7(5):648–657. doi: 10.1089/can.2021.0108

FIG. 1.

FIG. 1.

CBD reduces nociceptive behaviors in male mice, but in combination with low-dose morphine, CBD does not evoke synergistic antinociceptive effects. (A) Summary of the time course corresponding to the composite pain score from 0 to 60 min after formalin injection (F(48,444)=1.424, p=0.0374; two-way repeated-measures ANOVA with Tukey's post-test) (Vehicle: n=12; CBD: n=12; CBD + Mor: n=6; Mor [1 mg/kg]: n=6; Mor [10 mg/kg]: n=6). Asterisks denote significant difference from high-dose morphine (10 mg/kg). (B) Summary graph showing the AUC during phase I of the formalin assay (F(4,37)=11.78, p<0.0001; one-way ANOVA with Tukey's post-test). (C) Summary graph showing the AUC during phase II of the formalin assay (F(4,37)=5.999, p=0.0008; one-way ANOVA with Tukey's post-test). *p<0.05, **p<0.01, ***p<0.001. ANOVA, analysis of variance; AUC, area under the curve.