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. 2022 Oct 12;7(5):648–657. doi: 10.1089/can.2021.0108

FIG. 2.

FIG. 2.

CBD alone or in combination with low-dose morphine does not reduce pain during phase I or phase II of the formalin test in female mice. (A) Summary of the time course corresponding to the composite pain score from 0 to 60 min after formalin injection (F(48,660)=4.181, p<0.0001; two-way repeated-measures ANOVA with Tukey's post-test) (Vehicle: n=12; CBD: n=12; CBD + Mor: n=12; Mor [1 mg/kg]: n=12; Mor [10 mg/kg]: n=12). Asterisks denote significant difference from high-dose morphine (10 mg/kg). (B) Summary graph showing the AUC during phase I of the formalin assay (F(4,55)=4.236, p=0.0046; one-way ANOVA with Tukey's post-test). (C) Summary graph showing the AUC during phase II of the formalin assay (F(4,55)=3.820, p=0.0082; one-way ANOVA with Tukey's post-test). *p<0.05, **p<0.01.