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. 2022 Oct 7;24(5):304–313. doi: 10.1089/cell.2021.0200

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© Lena Böhnke, et al., 2022. Published by Mary Ann Liebert, Inc.

This open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 2. — (A) TGFβ signaling pathway with TGFβ1 and BMP signaling arm-specific receptors and inhibitors tSMADi (dark blue), Noggin (turquoise), and DMH1 (orange). (B) Generation of fibroblast-derived iNs in three different neuronal conversion media (tSMADi, +Noggin, and +DMH1) over 21 days. (C) Brightfield images of CL01 before (D-1) and after (D0) pool split, and during (D7, D14, and D21) conversion in three different neuronal conversion media (tSMADi, +Noggin, and +DMH1). Scale bars: 50 μm. DMH1, dorsomorphin homolog 1.